Researcher biography
After receiving a PhD on immune regulation from La Sorbonne Universitas in France, Anne-Sophie joined Prof. Ian Frazer’s lab in Australia where she led a highly successful and independent research program on the mechanisms of immune tolerance in human papillomavirus (HPV)-associated lesions in mice. She then joined the field of autoimmune diseases with Prof. Ranjeny Thomas. In Type 1 Diabetes, her pre-clinical data showed the feasibility of an antigen-specific liposome targeted immunotherapy in pre-diabetic mice and led to the first-in-human clinical trial using liposome nanoparticles. In Spondyloarthropathy, her interest is focused on deciphering the link between the gut microbiome, the immune system and the development of arthritic inflammation.
Journal Articles
Bhuyan, Zaied Ahmed, Rahman, M. Arifur, Maradana, Muralidhara Rao, Mehdi, Ahmed M., Bergot, Anne-Sophie, Simone, Davide, El-Kurdi, Marya, Garrido-Mesa, Jose, Cai, Cheng Bang Benjamin, Cameron, Amy J., Hanson, Aimee L., Nel, Hendrik J., Kenna, Tony, Leo, Paul, Rehaume, Linda, Brown, Matthew A., Ciccia, Francesco and Thomas, Ranjeny (2022). Genetically encoded Runx3 and CD4+ intestinal epithelial lymphocyte deficiencies link SKG mouse and human predisposition to spondyloarthropathy. Clinical Immunology, 247 109220, 109220. doi: 10.1016/j.clim.2022.109220
Okada, Mirei, Zhang, Vivian, Loaiza Naranjo, Jeniffer D., Tillett, Bree J., Wong, F. Susan, Steptoe, Raymond J., Bergot, Anne‐Sophie and Hamilton‐Williams, Emma E (2022). Islet‐specific CD8+ T cells gain effector function in the gut lymphoid tissues via bystander activation not molecular mimicry. Immunology and Cell Biology, 101 (1), 36-48. doi: 10.1111/imcb.12593
Giri, Rabina, Hoedt, Emily C., Khushi, Shamsunnahar, Salim, Angela A., Bergot, Anne-Sophie, Schreiber, Veronika, Thomas, Ranjeny, McGuckin, Michael A., Florin, Timothy H., Morrison, Mark, Capon, Robert J., Ó Cuív, Páraic and Begun, Jakob (2022). Secreted NF-κB suppressive microbial metabolites modulate gut inflammation. Cell Reports, 39 (2) 110646, 110646. doi: 10.1016/j.celrep.2022.110646
Buckle, Irina, Loaiza Naranjo, Jeniffer D., Bergot, Anne-Sophie, Zhang, Vivian, Talekar, Meghna, Steptoe, Raymond J., Thomas, Ranjeny and Hamilton-Williams, Emma E. (2022). Tolerance induction by liposomes targeting a single CD8 epitope IGRP in a model of type 1 diabetes is impeded by co-targeting a CD4 islet epitope. Immunology and Cell Biology, 100 (1), 33-48. doi: 10.1111/imcb.12506
Guggino, Giuliana, Mauro, Daniele, Rizzo, Aroldo, Alessandro, Riccardo, Raimondo, Stefania, Bergot, Anne-Sophie, Rahman, M Arifur, Ellis, Jonathan J., Milling, Simon, Lories, Rik, Elewaut, Dirk, Brown, Matthew A., Thomas, Ranjeny and Ciccia, Francesco (2021). Inflammasome activation in ankylosing spondylitis is associated to gut dysbiosis. Arthritis and Rheumatology, 73 (7) art.41644, 1189-1199. doi: 10.1002/art.41644
Narsale, Aditi, Lam, Breanna, Moya, Rosa, Lu, TingTing, Mandelli, Alessandra, Gotuzzo, Irene, Pessina, Benedetta, Giamporcaro, Gianmaria, Geoffrey, Rhonda, Buchanan, Kerry, Harris, Mark, Bergot, Anne-Sophie, Thomas, Ranjeny, Hessner, Martin J., Battaglia, Manuela, Serti, Elisavet and Davies, Joanna D. (2021). CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes. JCI Insight, 6 (2) e136114. doi: 10.1172/jci.insight.136114
Musthaffa, Yassmin, Hamilton‐Williams, Emma E, Nel, Hendrik J., Bergot, Anne‐Sophie, Mehdi, Ahmed M., Harris, Mark and Thomas, Ranjeny (2021). Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetes. Clinical & Translational Immunology, 10 (7) e1315, e1315. doi: 10.1002/cti2.1315
Loaiza Naranjo, Jeniffer D., Bergot, Anne-Sophie, Buckle, Irina and Hamilton-Williams, Emma E. (2020). A Question of Tolerance—Antigen-Specific Immunotherapy for Type 1 Diabetes. Current Diabetes Reports, 20 (12) 70, 70. doi: 10.1007/s11892-020-01363-3
Bergot, Anne-Sophie, Giri, Rabina and Thomas, Ranjeny (2020). The microbiome and rheumatoid arthritis. Best Practice and Research: Clinical Rheumatology, 33 (6) 101497, 101497. doi: 10.1016/j.berh.2020.101497
Bergot, Anne-Sophie, Buckle, Irina, Cikaluru, Sumana, Naranjo, Jennifer Loaiza, Wright, Casey Maree, Zheng, Guoliang, Talekar, Meghna, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2020). Regulatory T cells induced by single-peptide liposome immunotherapy suppress islet-Specific T cell responses to multiple antigens and protect from autoimmune diabetes. Journal of Immunology, 204 (7), ji1901128-1797. doi: 10.4049/jimmunol.1901128
Bhat, Purnima, Bergot, Anne-Sophie, Waterhouse, Nigel and Frazer, Ian Hector (2017). Human papillomavirus E7 oncoprotein expression by keratinocytes alters the cytotoxic mechanisms used by CD8 T cells. Oncotarget, 9 (5), 6015-6027. doi: 10.18632/oncotarget.23210
Hamilton-Williams, Emma E., Bergot, Anne-Sophie, Reeves, Peta L. S and Steptoe, Raymond J. (2016). Maintenance of peripheral tolerance to islet antigens. Journal of Autoimmunity, 72, 118-125. doi: 10.1016/j.jaut.2016.05.009
Ramnath, Divya, Tunny, Kathryn, Hohenhaus, Daniel M., Pitts, Claire M., Bergot, Anne-Sophie, Hogarth, P. Mark, Hamilton, John A., Kapetanovic, Ronan, Sturm, Richard A., Scholz, Glen M. and Sweet, Matthew J. (2015). TLR3 drives IRF6-dependent IL-23p19 expression and p19/EBI3 heterodimer formation in keratinocytes. Immunology and Cell Biology, 93 (9), 771-779. doi: 10.1038/icb.2015.77
Bergot, Anne-Sophie, Chaara, Wahiba, Ruggiero, Eliana, Mariotti-Ferrandiz, Encarnita, Dulauroy, Sophie, Schmidt, Manfred, von Kalle, Christof, Six, Adrien and Klatzmann, David (2015). TCR sequences and tissue distribution discriminate the subsets of naïve and activated/memory Treg cells in mice. European Journal of Immunology, 45 (5), 1524-1534. doi: 10.1002/eji.201445269
McKee, Sara J., Bergot, Anne-Sophie and Leggatt, Graham R. (2015). Recent progress in vaccination against human papillomavirus-mediated cervical cancer. Reviews in Medical Virology, 25 (S1), 54-71. doi: 10.1002/rmv.1824
Bergot, Anne-Sophie, Monnet, Nastasia, Tran, Son Le, Mittal, Deepak, Al-Kouba, Jane, Steptoe, Raymond J., Grimbaldeston, Michele A., Frazer, Ian H. and Wells, James W. (2015). HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions. Immunology and Cell Biology, 93 (6), 540-547. doi: 10.1038/icb.2014.123
Bergot, Anne-Sophie, Ford, Neill, Leggatt, Graham R., Wells, James W., Frazer, Ian H. and Grimbaldeston, Michele A. (2014). HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells. PLoS Pathogens, 10 (10), 1-11. doi: 10.1371/journal.ppat.1004466
Tran, Le Son, Bergot, Anne-Sophie, Mattarollo, Stephen R., Mittal, Deepak and Frazer, Ian H. (2014). Human papillomavirus E7 oncoprotein transgenic skin develops an enhanced inflammatory response to 2,4-dinitrochlorobenzene by an arginase-1-dependent mechanism. Journal of Investigative Dermatology, 134 (9), 2438-2446. doi: 10.1038/jid.2014.186
Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013). Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 (12), 2686-2694. doi: 10.1038/jid.2013.222
Chen, Ting, Darrasse-Jeze, Guillaume, Bergot, Anne-Sophie, Courau, Tristan, Churlaud, Guillaume, Valdivia, Karina, Strominger, Jack L., Ruocco, Maria Grazia, Chaouat, Gerard and Klatzmann, David (2013). Self-specific memory regulatory T cells protect embryos at implantation in mice. The Journal of Immunology, 191 (5), 2273-2281. doi: 10.4049/jimmunol.1202413
Gottrand, Gaëlle, Taleb. Kahina, Ragon, Isabelle, Bergot, Anne-Sophie, Goldstein, Jeremie D. and Marodon, Gilles (2012). Intrathymic injection of lentiviral vector curtails the immune response in the periphery of normal mice. Journal of Gene Medicine, 14 (2), 90-99. doi: 10.1002/jgm.1650
Bergot, Anne-Sophie, Kassianos, Andrew, Frazer, Ian H. and Mittal, Deepak (2011). New approaches to immunotherapy for HPV associated cancer. Cancers, 3 (3), 3461-3495. doi: 10.3390/cancers3033461
Bergot, A-S., Durgeau, A., Levacher, B., Colombo, B. M., Cohen, J. L. and Klatzmann, D. (2010). Antigen quality determines the efficiency of antitumor immune responses generated in the absence of regulatory T cells. Cancer Gene Therapy, 17 (9), 645-654. doi: 10.1038/cgt.2010.21
Gourdain, Pauline, Gregoire, Sylvie, Iken, Saci, Bachy, Veronique, Dorban, Gauthier, Chaigneau, Thomas, Debiec, Hanna, Bergot, Anne-Sophie, Renault, Isabelle, Aucouturier, Pierre and Carnaud, Claude (2009). Adoptive Transfer of T Lymphocytes Sensitized against the Prion Protein Attenuates Prion Invasion in Scrapie-Infected Mice. Journal of Immunology, 183 (10), 6619-6628. doi: 10.4049/jimmunol.0804385
Darrasse-Jeze, Guillaume, Bergot, Anne-Sophie, Durgeau, Aurelie, Billiard, Fabienne, Salomon, Benoit L., Cohen, Jose L., Bellier, Bertrand, Podsypanina, Katrina and Klatzmann, David (2009). Tumor emergence is sensed by self-specific CD44(hi) memory Tregs that create a dominant tolerogenic environment for tumors in mice. Journal of Clinical Investigation, 119 (9), 2648-2662. doi: 10.1172/JCI36628
Sacquin, Antoine, Bergot, Anne Sophie, Aucouturier, Pierre and Bruley-Rosset, Martine (2008). Contribution of antibody and T cell-specific responses to the progression of 139A-scrapie in C57BL/6 mice immunized with prion protein peptides. Journal of Immunology, 181 (1), 768-775. doi: 10.4049/jimmunol.181.1.768
Chaput, Nathalie, Darrasse-Jeze, Guillaume, Bergot, Anne-Sophie, Cordier, Corinne, Ngo-Abdalla, Stacie, Klatzmann, David and Azogui, Orly (2007). Regulatory T cells prevent CD8 T cell maturation by inhibiting CD4 th cells at tumor sites. Journal of Immunology, 179 (8), 4969-4978. doi: 10.4049/jimmunol.179.8.4969
Gregoire, S, Bergot, AS, Feraudet, C, Carnaud, C, Aucouturier, P and Rosset, MB (2005). The murine B cell repertoire is severely selected against endogenous cellular prion protein. Journal of Immunology, 175 (10), 6443-6449. doi: 10.4049/jimmunol.175.10.6443
Conference Papers
Narsale, A., Moya, R., Robertson, H., Payne, D., Lu, T. T., Geoffery, R., Buchanan, K., Harris, M., Bergot, A. S., Thomas, R., Hessner, M., Battaglia, M., Serti, E. and Davies, J. (2019). CD4+CD25+CD127HI cells correlate with length of remission in type 1 diabetes: validated in a multi-site study. International Conference on Lymphocyte Engineering (ICLE), London, United Kingdom, 13-15 September 2019. New Rochelle, NY United States: Mary Ann Liebert. doi: 10.1089/hum.2019.29091.abstracts
Bergot, A. S., Buckle,, Wright, C., Talekar, M., Hamilton-Williams, E. and Thomas, R. (2018). Antigen-Specific CD4 regulation by Liposomes encapsulating calcitriol and ChgA mimotope in NOD mice. 15th International Symposium on Dendritic Cells (DC), Aachen, Germany, 10-14 June 2018. Hoboken, NJ, United States: Wiley. doi: 10.1002/eji.201871000
Bergot, Anne-Sophie, Talekar, Meghna, Nel, Hanno, Galea, Ryan, Harris, Mark, Hamilton-Williams, Emma and Thomas, Ranjeny (2017). Antigen specific immunotherapy for autoimmune disease targeting dendritic cells. 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS), Kanazawa Japan, 29 October - 2 November 2017. London United Kingdom: Elsevier.
Bergot, A. S., Le Tran, S., Mittal, D., Grimbaldeston, M. A. and Frazer, I. H. (2012). Expression of HPV16-E7 oncoprotein in skin exacerbates the contact hypersensitivity response to DNCB. European Congress of Immunology, Glasgow Scotland, 5-8 September 2012. West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/imm.12002
Klatzmann, David, Maury, Sebastien, Darrasse-Jeze, Guillame, Bergot, Anne-Sophie, Podsypanina, Katrina, Lemoine, Francois and Cohen, Jose L. (2009). Regulatory T cells and cancer immunotherapy: Revision of the immunosurveillance of cancer paradigm and therapeutic consequences. Combined Meeting of the 17th European-Society-of-Gene-and-Cell-Therapy/16th German-Society-for-Gene-Therapy/4th German-Society-for-Stem-Cell-Research, Hannover Germany, Nov 21-25, 2009. MARY ANN LIEBERT INC.