Dr Vivian Zhang

Loh, Zhixuan, Simpson, Jennifer, Ullah, Ashik, Zhang, Vivian, Gan, Wan J., Lynch, Jason P., Werder, Rhiannon B., Sikder, Al Amin, Lane, Katie, Sim, Choon Boon, Porrello, Enzo, Mazzone, Stuart B., Sly, Peter D., Steptoe, Raymond J., Spann, Kirsten M., Sukkar, Maria B., Upham, John W. and Phipps, Simon (2020). HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling. PLoS Pathogens, 16 (7) e1008651, 1-21. doi: 10.1371/journal.ppat.1008651

Simpson, Jennifer, Loh, Zhixuan, Ullah, Md Ashik, Lynch, Jason P., Werder, Rhiannon B., Collinson, Natasha, Zhang, Vivian, Dondelinger, Yves, Bertrand, Mathieu J M, Everard, Mark L., Blyth, Christopher C., Hartel, Gunter, Van Oosterhout, Antoon J., Gough, Peter J., Bertin, John, Upham, John W., Spann, Kirsten M. and Phipps, Simon (2020). Respiratory syncytial virus infection promotes necroptosis and HMGB1 release by airway epithelial cells. American Journal of Respiratory and Critical Care Medicine, 201 (11), 1358-1371. doi: 10.1164/rccm.201906-1149OC

Lynch, Jason P., Werder, Rhiannon B., Curren, Bodie F., Sikder, Md. Al Amin, Ullah, Ashik, Sebina, Ismail, Rashid, Ridwan B., Zhang, Vivian, Upham, John W., Hill, Geoff R., Steptoe, Raymond J. and Phipps, Simon (2020). Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma. Mucosal Immunology, 13 (4), 652-664. doi: 10.1038/s41385-020-0268-8

Werder, Rhiannon B., Lynch, Jason P., Simpson, Jennifer C., Zhang, Vivian, Hodge, Nick H., Poh, Matthew, Forbes-Blom, Elizabeth, Kulis, Christina, Smythe, Mark L., Upham, John W., Spann, Kirsten, Everard, Mark L. and Phipps, Simon (2018). PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production. Science Translational Medicine, 10 (440) eaao0052, eaao0052. doi: 10.1126/scitranslmed.aao0052

Werder, Rhiannon B, Zhang, Vivian, Lynch, Jason P, Snape, Natale, Upham, John W, Spann, Kirsten and Phipps, Simon (2018). Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity. The Journal of allergy and clinical immunology, 141 (5), 1607-1619.e9. doi: 10.1016/j.jaci.2017.07.051

Lynch, Jason P., Werder, Rhiannon B., Loh, Zhixuan, Sikder, Md Al Amin, Curren, Bodie, Zhang, Vivian, Rogers, Matthew J. , Lane, Katie, Simpson, Jennifer, Mazzone, Stuart B., Spann, Kirsten, Hayball, John, Diener, Kerrilyn, Everard, Mark L., Blyth, Christopher C., Forstner, Christian, Dennis, Paul G., Murtaza, Nida, Morrison, Mark, Ó Cuív, Páraic, Zhang, Ping, Haque, Ashraful, Hill, Geoffrey R., Sly, Peter D., Upham, John W. and Phipps, Simon (2017). Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion. The Journal of Experimental Medicine, 215 (2), 537-557. doi: 10.1084/jem.20170298

Simpson, Jennifer, Lynch, Jason P., Loh, Zhixuan, Zhang, Vivian, Werder, Rhiannon B., Spann, Kirsten and Phipps, Simon (2017). The Absence of Interferon-β Promotor Stimulator-1 (IPS-1) Predisposes to Bronchiolitis and Asthma-like Pathology in Response to Pneumoviral Infection in Mice. Scientific Reports, 7 (1) 2353, 2353. doi: 10.1038/s41598-017-02564-9

Arikkatt, Jaisy, Ullah, Md Ashik, Short, Kirsty Renfree, Zhang, Vivian, Gan, Wan Jun, Loh, Zhixuan, Werder, Rhiannon B., Simpson, Jennifer, Sly, Peter D., Mazzone, Stuart B., Spann, Kirsten M., Ferreira, Manuel A R., Upham, John W., Sukkar, Maria B. and Phipps, Simon (2017). RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma. eLife, 6 e21199. doi: 10.7554/eLife.21199

Lynch, Jason P., Werder, Rhiannon B., Simpson, Jennifer, Loh, Zhixuan, Zhang, Vivian, Haque, Ashraful, Spann, Kirsten, Sly, Peter D., Mazzone, Stuart B., Upham, John W. and Phipps, Simon (2016). Aeroallergen-induced IL-33 predisposes to respiratory virus–induced asthma by dampening antiviral immunity. Journal of Allergy and Clinical Immunology, 138 (5), 1326-1337. doi: 10.1016/j.jaci.2016.02.039

Duong, Khang M., Arikkatt, Jaisy, Ullah, M. Ashik, Lynch, Jason P., Zhang, Vivian, Atkinson, Kerry, Sly, Peter D. and Phipps, Simon (2015). Immunomodulation of airway epithelium cell activation by mesenchymal stromal cells ameliorates house dust mite-induced airway inflammation in mice. American Journal of Respiratory Cell and Molecular Biology, 53 (5), 615-624. doi: 10.1165/rcmb.2014-0431OC

Foo, Shen Yun, Zhang, Vivian, Lalwani, Amit, Lynch, Jason P., Zhuang, Aowen, Lam, Chuan En, Foster, Paul S., King, Cecile, Steptoe, Raymond J., Mazzone, Stuart B., Sly, Peter D. and Phipps, Simon (2015). Regulatory T cells prevent inducible BALT formation by dampening neutrophilic inflammation. Journal of Immunology, 194 (9), 4567-4576. doi: 10.4049/jimmunol.1400909

Edwards, Chelsea L., Zhang, Vivian, Werder, Rhiannon B., Best, Shannon E., Sebina, Ismail, James, Kylie R., Faleiro, Rebecca J., Rivera, Fabian de Labastida, Amante, Fiona H., Engwerda, Christian R., Phipps, Simon and Haque, Ashraful (2015). Coinfection with blood-stage plasmodium promotes systemic type I interferon production during pneumovirus infection but impairs inflammation and viral control in the lung. Clinical and Vaccine Immunology, 22 (5), 477-483. doi: 10.1128/CVI.00051-15

Ullah, Md Ashik, Revez, Joana A., Loh, Zhixuan, Simpson, Jennifer, Zhang, Vivian, Bain, Lisa, Varelias, Antiopi, Rose-John, Stefan, Blumenthal, Antje, Smyth, Mark J., Hill, Geoffrey R., Sukkar, Manuel A. R, Ferreira M. A. R. and Phipps, Simon (2015). Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation. Journal of Allergy and Clinical Immunology, 136 (4), 1065-1073. doi: 10.1016/j.jaci.2015.02.032

Ullah, Md Ashik, Loh, Zhixuan, Gan, Wan Jun, Zhang, Vivian, Yang, Huan, Li, Jian Hua, Yamamoto, Yasuhiko, Schmidt, Ann Marie, Armour, Carol L., Hughes, J. Margaret, Phipps, Simon and Sukkar, Maria B. (2014). Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation. Journal of Allergy and Clinical Immunology, 134 (2), 440-450.e3. doi: 10.1016/j.jaci.2013.12.1035

Spann, Kirsten M., Loh, Zhixuan, Lynch, Jason P., Ullah, Ashik, Zhang, Vivian, Baturcam, Engin, Werder, Rhiannon B., Khajornjiraphan, Natthida, Rudd, Penny, Loo, Yeuh-Ming, Suhrbier, Andreas, Gale Jr., Michael, Upham, John W. and Phipps, Simon (2014). IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice. American Journal of Pathology, 184 (6), 1795-1806. doi: 10.1016/j.ajpath.2014.02.026

Barry, Jessica, Loh, Zhixuan, Colliso, Adam, Mazzone, Stuart, Lalwani, Amit, Zhang, Vivian, Davidson, Sophia, Wybacz, Elish, Garlanda, Cecilia, Mantovani, Alberto, Mattes, Joerg, Foster, Paul S. and Phipps, Simon (2013). Absence of toll-IL-1 receptor 8/single immunoglobulin IL-1 receptor-related molecule reduces house dust mite-induced allergic airway inflammation in mice. American Journal of Respiratory Cell and Molecular Biology, 49 (3), 481-490. doi: 10.1165/rcmb.2012-0425OC

Davidson, Sophia, Kaiko, Gerard, Loh, Zhixuan, Lalwani, Amit, Zhang, Vivian, Spann, Kirsten, Foo, Shen Yun, Hansbro, Nicole, Uematsu, Satoshi, Akira, Shizuo, Matthaei, Klaus I., Rosenberg, Helene F., Foster, Paul S. and Phipps, Simon (2011). Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway. Journal of Immunology, 186 (10), 5938-5948. doi: 10.4049/jimmunol.1002635

Werder, R., Hodge, N., Lynch, J., Simpson, J., Zhang, V, Forbes-Blom, E., Upham, J., Spann, K., Everard, M. and Phipps, S. (2016). Prostaglandin D2 contributes to severity of pneumoviral bronchiolitis. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Perth, WA Australia, 1-6 April 2016. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.

Werder, R., Lynch, J., Simpson, J., Loh, Z., Zhang, V., Spann, K., Sly, P., Mazzone, S., Upham, J. and Phipps, S. (2016). Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening type I and III interferon production. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200

Ullah, Ashik M., Pharm, M., Revez, J., Loh, Z., Simpson, J., Zhang, V, Bain, L., Varelias, A., Rose-John, S., Blumenthal, A., Smyth, M., Hill, G., Sukkar, M., Ferreira, M. and Phipps, S. (2015). Il-6R Blockade Attenuates Experimental Allergic Asthma Associated with Activation of the Il-6 Trans-Signalling Pathway. Annual Scientific Meeting 2015 of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Gold Coast, QLD Australia, 27 March - 1 April 2015. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12494_9

Loh, Z., Ullah, A., Zhang, V., Lynch, J., Werder, R., Simpson, J., Upham, J., Mazzone, S., Spann, K. and Phipps, S. (2015). Interferon Regulatory Factor 7 Protects Against Pneumovirus-Induced Airway Smooth Muscle Growth in Early Life. TSANZ 2015 Annual Scientific Meeting, Gold Coast, QLD Australia, 28 March - 1 April 2015. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12494_7

Werder, Rhiannon B., Lynch, Jason P., Simpson, Jennifer, Loh, Ken, Zhang, Vivian, Spann, Kirsten, Sly, Peter D., Mazzone, Stuart, Upham, John W. and Phipps, Simon (2014). Critical role for IL-33 in the onset and progression of experimental asthma induced by concomitant virus infection and allergen exposure. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne, VIC, Australia, October 26 - 29, 2014. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.203

Lynch, J., Werder, R. B., Simpson, J., Loh, Z., Zhang, V., Sly, P. D., Mazzone, S., Upham, J. W. and Phipps, S. (2014). Anti-IL-33 ameliorates asthma onset and progression in response to virus and allergen co-exposure. Abstracts of the British Society for Immunology Annual Congress, Brighton, United Kingdom, 1–4 December 2014. Chichester, West Sussex United Kingdom: Wiley-Blackwell Publishing.

Ullah, M. A., Loh, Z., Gan, W. J., Zhang, V., Lynch, J., Eacharath, J., Hughes, J. M., Armour, C. L., Phipps, S. and Sukkar, M. B. (2013). Hmgb1-Rage Axis Mediates House Dust Mite Induced Allergic Sensitization and Airway Inflammation. 2013 Annual Scientific Meetings of The Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science, Darwin, NT Australia, 22 - 27 March 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12045

Ullah, MD Ashik, Gan, Wan J., Loh, Zhixuan, Zhang, Vivian, Hughes, J. Margaret, Armour, Carol L., Phipps, Simon and Sukkar, Maria B. (2012). The activation of the receptor for advanced glycation end products (RAGE) contributes to the induction of Hdm-specific T(h)2 responses. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2012 Annual Scientific Meetings, Canberra, ACT, Australia, 30 March - 4 April 2012. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1843.2012.02142.x

Dr Vivian Zhang

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