Dr Sandra Pavey
Institute Manager
The University of Queensland Diamantina Institute
+61 7 344 36934
Book Chapter
Spoerri, Loredana, Oo, Zay Yar, Larsen, Jill E., Haass, Nikolas K., Gabrielli, Brian and Pavey, Sandra (2015). Cell cycle checkpoint and DNA damage response defects as anticancer targets: from molecular mechanisms to therapeutic opportunities.. In Georg T. Wondrak (Ed.), Stress response pathways in cancer: from molecular targets to novel therapeutics (pp. 29-49) Dordrecht: Springer Science+Business Media. doi:10.1007/978-94-017-9421-3_3
Journal Articles
Singhania, Richa, Pavey, Sandra, Payne, Elizabeth, Gu, Wenyi, Clancy, Jennifer, Jubair, Luqman, Preiss, Thomas, Saunders, Nicholas and McMillan, Nigel A. J. (2016) Short interfering RNA induced generation and translation of stable 5' mRNA cleavage intermediates. Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1859 8: 1034-1042. doi:10.1016/j.bbagrm.2016.06.005
Fox, Carly, Lambie, Duncan, Wilmott, James S., Pinder, Alex, Pavey, Sandra, Lê Cao, Kim-Anh, Akalin, Taner, Karaarslan, Isil Kilinc, Ozdemir, Fezal, Scolyer, Richard A., Yamada, Miko, Soyer, H. Peter, Schaider, Helmut and Gabrielli, Brian (2016) Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation. Pigment Cell and Melanoma Research, 29 4: 444-452. doi:10.1111/pcmr.12489
Spoerri, Loredana, Brooks, Kelly, Chia, KeeMing, Grossman, Gavriel, Ellis, Jonathan J., Dahmer-Heath, Mareike, Skalamera, Dubravka, Pavey, Sandra, Burmeister, Bryan and Gabrielli, Brian (2016) A novel ATM-dependent checkpoint defect distinct from loss of function mutation promotes genomic instability in melanoma. Pigment Cell and Melanoma Research, 29 3: 329-339. doi:10.1111/pcmr.12466
Vaidyanathan, Srividya, Cato, Kathleen, Tang, Lu, Pavey, Sandra, Haass, Nikolas K., Gabrielli, Brian G. and Duijf, Pascal H. G. (2016) In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis. Oncogene, 35 41: 5446-5455. doi:10.1038/onc.2016.94
Oakes, Vanessa, Wang, Weili, Harrington, Brittney, Lee, Won Jae, Beamish, Heather, Chia, Kee Ming, Pinder, Alex, Goto, Hidemasa, Inagaki, Masaki, Pavey, Sandra and Gabrielli, Brian (2014) Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle. Cell Cycle, 13 20: 3302-3311. doi:10.4161/15384101.2014.949111
Brooks, Kelly, Ranall, Max, Spoerri, Loredana, Stevenson, Alex, Gunasingh, Gency, Pavey, Sandra, Meunier, Fred, Gonda, Thomas J. and Gabrielli, Brian (2014) Decatenation checkpoint defective melanomas are dependent on PI3K for survival. Pigment Cell and Melanoma Research, 27 5: 813-821. doi:10.1111/pcmr.12268
Pavey, Sandra, Spoerri, Loredana, Haass, Nikolas K. and Gabrielli, Brian (2013) DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.. Pigment Cell and Melanoma Research, 26 6: 805-816. doi:10.1111/pcmr.12136
Brooks, Kelly, Chia, Kee Ming, Spoerri, Loredana, Mukhopadhyay, Pamela, Wigan, Matthew, Stark, Mitchell, Pavey, Sandra and Gabrielli, Brian (2013) Defective decatenation checkpoint function is a common feature of melanoma. Journal of Investigative Dermatology, 134 1: 150-158. doi:10.1038/jid.2013.264
Kendall, Bradley J., Macdonald, Graeme A., Hayward, Nicholas K., Prins, Johannes B., O'Brien, Suzanne, Whiteman, David C., Study of Digestive Health, Green. Adele C., Parsons, Peter G., Pavey, Sandra J., Purdie, David M. and Webb, Penelope M. (2013) The risk of Barrett's esophagus associated with abdominal obesity in males and females. International Journal of Cancer, 132 9: 2192-2199. doi:10.1002/ijc.27887
Brooks, K., Oakes, V., Edwards, B., Ranall, M., Leo, P., Pavey, S., Pinder, A., Beamish, H., Mukhopadhyay, P., Lambie, D. and Gabrielli, B. (2013) A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress. Oncogene, 32 6: 788-796. doi:10.1038/onc.2012.72
Wigan, Matthew, Pinder, Alex, Giles, Nichole, Pavey, Sandra, Burgess, Andrew, Wong, ShuShyan, Sturm, Rick A. and Gabrielli, Brian (2012) A UVR-induced G2-phase checkpoint response to ssDNA gaps produced by replication fork bypass of unrepaired lesions is defective in melanoma. Journal of Investigative Dermatology, 132 6: 1681-1688. doi:10.1038/jid.2012.41
Gabrielli, Brian, Brooks, Kelly and Pavey, Sandra (2012) Defective cell cycle checkpoints as targets for anti-cancer therapies. Frontiers in Pharmacology, 3 9: 9.1-9.6. doi:10.3389/fphar.2012.00009
Giles, N., Pavey, S., Pinder, A. and Gabrielli, B. (2012) Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skin. British Journal of Dermatology, 166 2: 362-371. doi:10.1111/j.1365-2133.2011.10635.x
Savarimuthu Francis, Santiyagu M., Larsen, Jill E., Pavey, Sandra J., Duhig, Edwina E., Clarke, Belinda E., Bowman, Rayleen V., Hayward, Nick K., Fong, Kwun M. and Yang, Ian A. (2011) Genes and gene ontologies common to airflow obstruction and emphysema in the lungs of patients with COPD. PLoS One, 6 3: . doi:10.1371/journal.pone.0017442
Mason, Sharon A., Cozzi, Sarah-Jane, Pierce, Carly J., Pavey, Sandra J., Parsons, Peter G. and Boyle, Glen M. (2010) The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells. Investigational New Drugs, 28 5: 575-586. doi:10.1007/s10637-009-9292-y
Dry, Jonathan R., Pavey, Sandra, Pratilas, Christine A., Harbron, Chris, Runswick, Sarah, Hodgson, Darren, Chresta, Christine, McCormack, Rose, Byrne, Natalie, Cockerill, Mark, Graham, Alexander, Beran, Garry, Cassidy, Andrew, Haggerty, Carolyn, Brown, Helen, Ellison, Gillian, Dering, Judy, Taylor, Barry S., Stark, Mitchell, Bonazzi, Vanessa, Ravishankar, Sugandha, Packer, Leisl, Xing, Feng, Solit, David B., Finn, Richard S., Rosen, Neal, Hayward, Nicholas K., French, Tim and Smith, Paul D. (2010) Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244). Cancer Research, 70 6: 2264-2273. doi:10.1158/0008-5472.CAN-09-1577
Francis, Santiyagu M. Savarimuthu, Larsen, Jill E., Pavey, Sandra J., Bowman, Rayleen V., Hayward, Nicholas K., Fong, Kwun M. and Yang, Ian A. (2009) Expression profiling identifies genes involved in emphysema severity. Respiratory Research, 10 1: 1-10. doi:10.1186/1465-9921-10-81
Smith, Eric, De Young, Neville J., Pavey, Sandra J., Hayward, Nicholas K., Nancarrow, Derek J., Whiteman, David C., Smithers, B. Mark, Ruszkiewicz, Andrew R., Clouston, Andrew D., Gotley, David C., Devitt, Peter G., Jamieson, Glyn G. and Drew, Paul A. (2008) Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma. Molecular Cancer, 7 75.1-75.12. doi:10.1186/1476-4598-7-75
Hacker, E., Muller, K., Whiteman, D. C., Pavey, S., Hayward, N. and Walker, G. (2008) Reduced expression of IL-18 is a marker of ultraviolet radiation-induced melanomas. International Journal of Cancer, 123 1: 227-231. doi:10.1002/ijc.23389
Larsen, J. E., Pavey, S., Passmore, L. H., Bowman, R., Clarke, B. E., Hayward, N. K. and Fong, K. M. (2007) Expression profiling defines a recurrence signature in lung squamous cell carcinoma. Carcinogenesis, 28 3: 760-766. doi:10.1093/carcin/bgl207
Packer, Leisl M., Pavey, Sandra J., Boyle, Glen M., Stark, Mitchell S., Ayub, Ana L., Rizos, Helen and Hayward, Nicholas K. (2007) Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF. International Journal of Cancer, 121 4: 784-790. doi:10.1002/ijc.22725
Johansson, Peter, Pavey, Sandra and Hayward, Nicholas (2007) Confirmation of a BRAF mutation-associated gene expression signature in melanoma. Pigment Cell and Melanoma Research, 20 3: 216-221. doi:10.1111/j.1600-0749.2007.00375.x
Larsen,J. E., Pavey, S., Passmore, L. H., Bowman, R. V., Hayward, N. K. and Fong, K. M. (2007) Gene expression signature predicts recurrence in lung adenocarcinoma. Clinical Cancer Research, 13 10: 2946-2954. doi:10.1158/1078-0432.CCR-06-2525
Zuidervaart, W., Pavey, S., van Nieuwpoort, F. A., Packer, L., Out, C., Maat, W., Jager, M. J., Gruis, N. A. and Hayward, N. K. (2007) Expression of Wnt5a and its downstream effector beta-catenin in uveal melanoma. Melanoma Research, 17 6: 380-386. doi:10.1097/CMR.0b013e3282f1d302
Larsen, J.E., Pavey, S.J., Bowman, R., Yang, I.A., Clarke, B.E., Colosimo, M.L., Hayward, N.K. and Fong, K.M. (2007) Gene expression of lung squamous cell carcinoma reflects mode of lymph node involvement. The European Respiratory Journal, 30 1: 21-25. doi:10.1183/09031936.00161306
Packer, Leisl, Pavey, Sandra, Parker, Andrew, Stark, Mitchell, Johansson, Peter, Clarke, Belinda, Pollock, Pamela, Ringner, Markus and Hayward, Nicholas (2006) Osteopontin is a Downstream Effector of the PI3-kinase Pathway in Melanomas that is Inversely Correlated with Functional PTEN. Carcinogenesis, 27 9: 1778-1786. doi:10.1093/carcin/bgl016
Pavey, Sandra, Zuidervaart, Wieke, van Nieuwpoort, Frans, Packer, Leisl, Jager, Martine, Gruis, Nelleke and Hayward, Nicholas (2006) Increased p21-activated kinase-1 expression is associated with invasive potential in uveal melanoma. Melanoma Research, 16 4: 285-296. doi:10.1097/01.cmr.0000222589.30117.f2
Hacker, E., Muller, H. K., Irwin, N., Gabrielli, B., Lincoin, D., Pavey, S., Powell, M. B., Malumbres, M., Barbacid, M., Hayward, N. and Walker, G. (2006) Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4(R24C/R24C)/TPras mice. Cancer Research, 66 6: 2946-2952. doi:10.1158/0008-5472.CAN-05-3196
Tonks, Ian D., Hacker, Elke, Irwin, Nicole, Muller, H. Conrad, Keith, Patricia, Mould, Arne, Zournazi, Anna, Pavey, Sandra, Hayward, Nicholas K., Walker, Graeme and Kay, Graham F. (2005) Melanocytes in conditional Rb–/– mice are normal in vivo but exhibit proliferation and pigmentation defects in vitro. Pigment Cell and Melanoma Research, 18 4: 252-264. doi:10.1111/j.1600-0749.2005.00245.x
Zuidervaart, W., van Nieuwpoort, F., Stark, M., Dijkman, R., Packer, L., Borgstein, A. -M., Pavey, S., van der Velden, P., Out, C., Jager, M. J., Hayward, N. K. and Gruis, N. A. (2005) Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS. British Journal of Cancer, 92 11: 2032-2038. doi:10.1038/sj.bjc.6602598
van der Velden, P. A., Zuidervaart, W., Hurks, M. H., Pavey, S., Ksander, B. R., Krijgsman, E., Frants, R. R., Tensen, C. P., Willemze, R., Jager, M. J. and Gruis, N. A. (2004) Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development (vol 106, pg 472, 2003). International Journal of Cancer, 111 6: 982-982. doi:10.1002/ijc.20479
Pavey, Sandra, Johansson, Peter, Packer, Leisl, Taylor, Jennifer, Stark, Mitchell, Pollock, Pamela M., Walker, Graeme J., Boyle, Glen M., Harper, Ursula, Cozzi, Sarah-Jane, Hansen, Katherine, Yudt, Laura, Schmidt, Chris, Hersey, Peter, Ellem, Kay A. O., O'Rourke, Michael G. E., Parsons, Peter G., Meltzer, Paul, Ringnér, Markus and Hayward, Nicholas K. (2004) Microarray expression profiling in melanoma reveals a BRAF mutation signature. Oncogene, 23 23: 4060-4067. doi:10.1038/sj.onc.1207563
Pavey, S. and Gabrielli, B. G. (2004) Analyzing checkpoint controls in human skin. Methods in Molecular Biology, 280 1: 175-183.
Van der Velden, Pieter A., Zuidervaart, Wieke, Hurks, Monique H. M. H., Pavey, Sandra, Ksander, Bruce R., Krijgsman, Elise, Frants, Rune R., Tensen, Cornelis P., Willemze, Rein, Jager, Martine J. and Gruis, Nelleke A. (2003) Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development. International Journal of Cancer, 106 4: 472-479. doi:10.1002/ijc.11262
Whiteman, David C., Zhou, Xiao-Ping, Cummings, Margaret C., Pavey, Sandra, Hayward, Nicholas K. and Eng, Charis (2002) Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma. International Journal of Cancer, 99 1: 63-67. doi:10.1002/ijc.10294
Pavey, S. J., Cummings, M. C., Whiteman, D. C., Castellano, M., Walsh, M. D., Gabrielli, B. G., Green, A. and Hayward, N. K. (2002) Loss of p16 expression is associated with histological features of melanoma invasion. Melanoma Research, 12 6: 539-547. doi:10.1097/01.cmr.0000043154.28051.9f
Pavey, S. and Gabrielli, B. (2002) alpha-melanocyte stimulating hormone potentiates p16/CDKN2A expression in human skin after ultraviolet irradiation. Cancer Research, 62 3: 875-880.
Pavey, S. J., Hawson, G. A. T. and Marsh, N. A. (2001) Impact of the fibrinolytic enzyme system on prognosis and survival associated with non-small cell lung carcinoma. Blood Coagulation and Fibrinolysis, 12 1: 51-58. doi:10.1097/00001721-200101000-00008
Pavey, Sandra, Russell, Terry and Gabrielli, Brian (2001) G2 phase cell cycle arrest in human skin following UV irradiation. Oncogene, 20 43: 6103-6110. doi:10.1038/sj.onc.1204707
Burgess, A. J., Pavey, S., Warrener, R., Hunter, L. J. K., Piva, T. J., Musgrove, E. A., Saunders, N., Parsons, P. G. and Gabrielli, B. G. (2001) Up-regulation of p21(WAF1)/(CIP1) by histone deacetylase inhibitors reduces their cytotoxicity. Molecular Pharmacology, 60 4: 828-837.
Goldstone, S., Pavey, S., Forrest, A., Sinnamon, J. and Gabrielli, B. (2001) Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR. Oncogene, 20 8: 921-932. doi:10.1038/sj.onc.1204177
Pavey, S. J., Hawson, G. A. T. and Marsh, N. A. (1999) Alterations to the fibrinolytic enzyme system in patients with non-small cell lung carcinoma. Blood Coagulation and Fibrinolysis, 10 5: 261-267. doi:10.1097/00001721-199907000-00007
Pavey, S. J., Conroy, S., Russell, T. and Gabrielli, B. (1999) Ultraviolet radiation induces p16CDKN2A expression in human skin. Cancer Research, 59 17: 4185-4189.
Conference Papers
Duijf, Pascal H. G., Vaidyanathan, Srividya, Cato, Kathleen, Thangavelu, Pulari U., Lin, Cheng-Yu, Tang, Lu, Pavey, Sandra, Haass, Nikolas K. and Gabrielli, Brian G. (2018). Overexpression of the cell cycle regulator Emi1 promotes chromosome instability and tumorigenesis. In: 76th Annual Meeting of the Japanese Cancer Association, Yokohama, Japan, (418). 28-30 September 2017. doi:10.1111/cas.13499
Lee, W. J., Skalamera, D., Dahmer, M., Shakhbazov, K., Purdon, A., Wilson, B., Ranall, M, Pinder, A., Pavey, S., Gonda, T. and Gabrielli, B. (2012). A Genome-wide Human ORF Gain-of-function Screen to Identify Genes that can Bypass p16INK4a-mediated Cellular Senescence. In: 6th Australian High Content Screening Group Meeting, Melbourne, Australia, (). 13th July 2012.
Lee, W. J., Skalamera, D., Dahmer, M., Shakhbazov, K., Ranall, M., Purdon, A., Wilson, B., Pinder, A., Pavey, S., Gonda, T. and Gabrielli, B. (2011). A functional genomics approach to identify genes and pathways that can bypass p16INK4a-mediated cellular senescence. In: 14th Annual Australian Cell Cycle Workshop, Noosa, Australia, (). 24 October 2011.
Wigan, M., Giles, N., Pavey, S. and Gabrielli, B. (2009). Suberythemal UV G2 phase checkpoint in response to post replication repair is defective in a majority of melanoma cell lines. In: ASDR Abstracts. 5th Annual Scientific Meeting of the Australasian Society for Dermatology Research, Sydney, Australia, (2918-2918). 21-22 May 2008. doi:10.1038/jid.2009.333
Giles, N., Pavey, S. and Gabrielli, B (2009). UVR induced ERK signaling pathway regulates p16 expression in skin. In: ASDR Abstracts. 5th Annual Scientific Meeting of the Australasian-Society-for-Dermatology-Research, Sydney, Australia, (2919-2919). 21-22 May 2008. doi:10.1038/jid.2009.333
Hacker, Elke, Muller, H. Konrad, Whiteman, David, Pavey, Sandra, Hayward, Nicholas and Walker, Graeme (2008). Decreased expression of IL18 in the pathway to ultraviolet radiation-induced melanoma. In: You have full text access to this content Abstracts of the Conjoint Meeting of XXth International Pigment Cell Conference & Vth International Melanoma Research Congress. Conjoint Meeting of XXth International Pigment Cell Conference & Vth International Melanoma Research Congress, Sapporo, Japan, (299-300). 7-12 May 2008. doi:10.1111/j.1755-148X.2008.00458_3.x
Smith, E., Nancarrow, D. J., Pavey, S., Hayward, N. K., de Young, N. J., Kelly, J.J., Whiteman, D. C., Struthers, B. M., Gotley, D. C. and Drew, P. A. (2006). Gene promoter methylation of ID4 and ARL4D in Barrett's esophagus and esophageal adenocarcinoma. In: Gastroenterology. Digestive Disease Week Meeting/107th Annual Meeting of the American Gastroenterological Association, Los Angeles, CA, United States, (A565-A565). 19-24 May 2006.
Schmidt, Christopher, Martinez, Nathan R., Neller, Michelle, Lai, M., Lopez, Jose Alejandro, Lanagan, Catherine M., O'Connor, Linda E., Nicholas, D., Johnson, Maree K., See, Janet L., Hallt, S., Slater, Gregory J., O'Rourke, Michael G. E., Pavey, Sandra, Hayward, Nick and Ellem, Kay A. O. (2005). Towards a response model for dendritic cell immunotherapy of advanced metastatic melanoma. In: Abstracts fo the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop. 35th Annual SCientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne, VIC, Australia, (533-533). 29 November - 2 December 2005. doi:10.1111/j.1399-0039.2005.00523.x
Lai, M., Hayward, N. K., Pavey, S., Schmidt, C. W. and Martinez, N. (2005). MHC class II expression may be associated with an objective response in melanoma patients undergoing dendritic cell immunotherapy. In: Genetics and The Immune Response’ Abstracts of the 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA and Immunogenetics Workshop. 35th Annual Scientific Meeting of the Australasian Society for Immunology/14th International HLA and Immunogenetics Workshops, Melbourne, Australia, (470-470). 29 November-2 December 2005. doi:10.1111/j.1399-0039.2005.00523.x
Larsen, J., Pavey, S., Passmore, L., Bowman, R., Hayward, N., Zimmerman, P. and Fong, K. (2005). Expression profiling of metastatic recurrence in primary bronchogenic squamous cell carcinomas. In: Lung Cancer. 11th World Conference on Lung Cancer, Barcelona, Spain, (S133-S133). 03-06 July 2005. doi:10.1016/S0169-5002(05)80568-9
Whiteman, D., Green, A., Hayward, N., Pavey, S., Purdie, D. and Webb, P. (2003). Molecular epidemiology of Barret's esophagus and cancer: A population-based case-control study. In: Cancer Epidemiology Biomarkers & Prevention.. 2nd Annual AACR International Conference on Frontiers in Cancer Prevention Research, Phoenix, Arizona,, (1349S-1350S). 26-30 October 2003.
Conference Item
Larsen, J., Pavey, S., Passmore, L., Bowman, R., Hayward, N., Zimmerman, P. and Fong, K. (2005). Expression profiling of metastatic recurrence in primary bronchogenic squamous cell. In: Lung Cancer. Abstract of the 11th World Conference on Lung Cancer. 11th World Conference on Lung Cancer 2005, Barcelona, Spain, (S133-S133). 3-6 July 2005. doi:10.1016/S0169-5002(05)80568-9