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Dr Sandra Pavey

Institute Manager
The University of Queensland Diamantina Institute
+61 7 344 36934
Dr Sandra Pavey

Publications

Book Chapter (1)
Journal Articles (43)
Conference Papers (11)
Conference Item (1)

Book Chapter

Cell cycle checkpoint and DNA damage response defects as anticancer targets: from molecular mechanisms to therapeutic opportunities.

Journal Articles

Short interfering RNA induced generation and translation of stable 5' mRNA cleavage intermediates
Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation
A novel ATM-dependent checkpoint defect distinct from loss of function mutation promotes genomic instability in melanoma
In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis
Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle
Decatenation checkpoint defective melanomas are dependent on PI3K for survival
DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.
Defective decatenation checkpoint function is a common feature of melanoma
The risk of Barrett's esophagus associated with abdominal obesity in males and females
A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress
A UVR-induced G2-phase checkpoint response to ssDNA gaps produced by replication fork bypass of unrepaired lesions is defective in melanoma
Defective cell cycle checkpoints as targets for anti-cancer therapies
Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skin
Genes and gene ontologies common to airflow obstruction and emphysema in the lungs of patients with COPD
The induction of senescence-like growth arrest by protein kinase C-activating diterpene esters in solid tumor cells
Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244)
Expression profiling identifies genes involved in emphysema severity
Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma
Reduced expression of IL-18 is a marker of ultraviolet radiation-induced melanomas
Expression profiling defines a recurrence signature in lung squamous cell carcinoma
Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF
Confirmation of a BRAF mutation-associated gene expression signature in melanoma
Gene expression signature predicts recurrence in lung adenocarcinoma
Expression of Wnt5a and its downstream effector beta-catenin in uveal melanoma
Gene expression of lung squamous cell carcinoma reflects mode of lymph node involvement
Osteopontin is a Downstream Effector of the PI3-kinase Pathway in Melanomas that is Inversely Correlated with Functional PTEN
Increased p21-activated kinase-1 expression is associated with invasive potential in uveal melanoma
Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4(R24C/R24C)/TPras mice
Melanocytes in conditional Rb–/– mice are normal in vivo but exhibit proliferation and pigmentation defects in vitro
Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS
Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development (vol 106, pg 472, 2003)
Microarray expression profiling in melanoma reveals a BRAF mutation signature
Analyzing checkpoint controls in human skin
Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development
Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma
Loss of p16 expression is associated with histological features of melanoma invasion
alpha-melanocyte stimulating hormone potentiates p16/CDKN2A expression in human skin after ultraviolet irradiation
Up-regulation of p21(WAF1)/(CIP1) by histone deacetylase inhibitors reduces their cytotoxicity
Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR
G2 phase cell cycle arrest in human skin following UV irradiation
Impact of the fibrinolytic enzyme system on prognosis and survival associated with non-small cell lung carcinoma
Alterations to the fibrinolytic enzyme system in patients with non-small cell lung carcinoma
Ultraviolet radiation induces p16CDKN2A expression in human skin

Conference Papers

Overexpression of the cell cycle regulator Emi1 promotes chromosome instability and tumorigenesis
A Genome-wide Human ORF Gain-of-function Screen to Identify Genes that can Bypass p16INK4a-mediated Cellular Senescence
A functional genomics approach to identify genes and pathways that can bypass p16INK4a-mediated cellular senescence
Suberythemal UV G2 phase checkpoint in response to post replication repair is defective in a majority of melanoma cell lines
UVR induced ERK signaling pathway regulates p16 expression in skin
Decreased expression of IL18 in the pathway to ultraviolet radiation-induced melanoma
Gene promoter methylation of ID4 and ARL4D in Barrett's esophagus and esophageal adenocarcinoma
MHC class II expression may be associated with an objective response in melanoma patients undergoing dendritic cell immunotherapy
Expression profiling of metastatic recurrence in primary bronchogenic squamous cell carcinomas
Towards a response model for dendritic cell immunotherapy of advanced metastatic melanoma
Molecular epidemiology of Barret's esophagus and cancer: A population-based case-control study

Conference Item

Expression profiling of metastatic recurrence in primary bronchogenic squamous cell