Upham Group - Lung and allergy research
About
Our group studies immune function in people with lung disease, especially asthma, chronic obstructive pulmonary disease and bronchiectasis.
The consistent theme of our program of translational research has been the study of immune function in people with chronic lung disease, with the aim of identifying novel therapeutic targets and interventions that impact on patient care. Our work spans the broad areas from discovery science through to clinical studies, clinical trials and changing clinical practice.
In the laboratory we use transcriptomics and proteomics to dissect the immune responses to common viruses, and identify predictors of ‘lung attacks’ i.e. exacerbations of asthma, COPD and bronchiectasis.
- Using proteomics to discover novel proteins in lung secretions that predict acute asthma attacks.
- Function of T regulatory cells in virus infections and in asthma
- Discovering novel ways to improve influenza vaccination
Student projects
Effects of rhinoviruses on dendritic cell checkpoint ligands
Grants
NHMRC grant success has included two previous Program Grants, two current Project Grants, and two Centres of Research Excellence in “Indigenous Lung Health” and “Severe Asthma”.
Partners
- Prince Charles Hospital
- The University of Newcastle
- The University of Melbourne